Endocrine Abstracts

Objective: Because the altered expression of superoxide dismutases, CuZn (SOD1) and Mn (SOD2) have been shown to constitute the basis of either resistance or susceptibility to the cytotoxic effect of various cytostatics and nucleoside drugs, we tested whether in human uterin cervix carcinoma cells (HeLaS3) the cytotoxic effect of cytostatics adriamycin (Adr), and cis-platinum (CP) or nucleoside drug, tiazofurin (TF) were involved in the activity of SOD1 and SOD2. Methods: Cyto...

Background: It has been shown that hypothyroidism is associated with atherosclerosis. The presence of atherosclerosis process could be registered by use of some Doppler Ultrasound parameters (DUP) – intima-media complex thickness (IMCT) and systolic velocity (SV). In this study we present initial DUP on the lower limb artery in treatment-naïve hypothyroid females and the influence of thyroid hormone levels and some metabolic components.Methods ...